Research on alternative forms of funding, some thoughts

With funding for research very tight (form governmental, foundational, and corporate sources) and my interest in alternative sources of funding, I decided to post some of my casual investigations into a new model for funding scientific inquiry and technological development.

Recently, I saw an interview with Nathan Myhrvold on Charlie Rose (a PBS show). Mr. Myhrvold, a former Microsoft employee, has created a company called Intellectual Ventures . Intellectual Ventures is an company that helps innovators file patents and extract monetary return from their investments in time and research. In the research that I have done, this type of arrangement has a lot of potential for academic pursuits. The goal is to translate ideas and (engineering) artifacts into a profitable enterprise. Overall, I like the mission of Intellectual Ventures. Yet patents are not the only means to extract profit from the landscape of ideas.

The patent system has at least three drawbacks to helping along modern innovation. Firstly, the initial cost of filing a patent is quite high. In University settings, this is mitigated somewhat, but still poses a problem for when multiple patents are sought. The costs add up, particularly if these patents ultimately bring in little money. Secondly, there is currently a backlog of applications at the patent office, which increases the time between initial submission and the awarding of the patent. Finally, patents are usually the result of research funded by one of the federal funding agencies. Therefore, extracting value from intellectual activity is
a drawn-out process that might benefit from the ability to extract value at the various intermediate steps.

One answer to some of these challenges might be found in project funding sites such as Kickstarter . Although Kickstarter is for activities with a more concrete endproduct than typical scientific research, it provides a means to raise small amounts of funds for initial and piecemeal advances.
I wrote a white paper earlier this year on establishing something similar to this before I started paying attention to Kickstarter (NOTE: my idea differs in that it directly supports the unique environment of scientific and other academic work). My future plans are to try and work with Kickstarter to develop small-scale projects that don't have concrete or "tangible" financial outcomes.

I will be posting more on this topic as I develop these ideas further.

Review of "Bursts"

Review of Barabasi, A-L. (2010). Bursts: the hidden pattern behind everything we do. Dutton Press, New York.

Introduction 

If you recollect your daily routine, what adjective would you use to describe it? What did you do today and in what order did you do these things? You probably engaged in an automatic routine, with many events being the same and some of those events occurring at roughly the same time from day to day. You also probably do things at the same time as your neighbor. Part of this is based on the way society is organized. Indeed, people tend to have similar schedules or engage in the same essential activities. But an alternative hypothesis suggests that statistical laws govern aggregate human (and natural) behavior. When processes such as travel across human transportation networks or e-mail correspondences unfold over time, they do so in a statistically distinct manner. In his previous book “Linked”, Barabasi got ahead of the social networking curve to demonstrate the power of connectedness to a general audience. Yet connectivity has two components: the static topology, and the dynamic, less-understood process of connection. In "Bursts", the argument is made that dynamic behavioral patterns (such as connecting to a network) can be characterized using a series of non-uniform statistical distributions. These models reveal that traffic jams, long check-out lines, and even crime waves are indeed not unpredictable events, but rather can be understood as "bursts" that occur at relatively infrequent intervals. Yet the very nature of their burstiness (in that they involve synchronized, collective behavior) makes them predictable.

Your daily schedule might involve brushing your teeth at a different time than your neighbor, but going to work at the same time. This is one kind of behavioral burst that is featured in Barabasi’s book. But we can also think of bursts as excitable events that occur against either a random background. We are all familiar with the excitability exhibited by exploding fireworks, popping popcorn, or even neurons firing an action potential. All of these events have one thing in common: nonlinear behavior governed by a threshold. In the case of both popcorn and neurons, a constant stimulus is applied that eventually triggers a change in state. In the case of both popcorn and neurons, these bursts only become useful in the context of collective behavior (one is immensely enjoyable, the other essential to your survival). Physicists sometimes refer to this type of response as a first-order phase transition. In the classic sandpile model of Bak, Tang, and Weisenfeld, the gradual growth of a sandpile is sometime punctuated by large-scale displacements in the structure of the sandpile. These large-scale displacements occur at low frequencies relative to the more uniform small-scale displacements. In many cases, the distribution of these events over time can be scaled to a power law (or 1/f) distribution, meaning that they are fundamentally distinct from a uniform diffusive process resulting in a Gaussian distribution of events. Any good book in statistical physics can put the significance of 1/f processes in context in addition to providing a wealth of specific examples in nature. But how do these well-characterize physical processes map to and help explain human behavioral bursts?

An Underlying Mechanism

One undercurrent of this book is that excitable events, synchronized, collective behavioral processes, and power law behavior are all part of the same subject. This subject is the manner in which bursts unfold, which is according to a Poisson process. While excitable events, collective behavioral processes, and power law behavior all set the stage for bursty events, it is the Poisson process that distributes these events stochastically with respect to time. In addition, power law behavior should be expected of a Poisson process that can be observed at all timescales. The investigation of e-mail archives demonstrates this: most e-mail arrives at specific times of day or on specific days of the week, with smaller clusters or singleton events occurring in the interim. The difference between e-mail archives and physical avalanches, however, is instructive. In the case of the former (e-mail), the "bursts" are due to large-scale events driven by intention. In the case of the latter (physical avalanche), the "bursts" are due to large-scale events driven by a buildup of forces that exceeds a threshold. In both cases, linear inputs act collectively to produce a nonlinear output. One could argue that the "flash crash" of May, 2010 was caused by the bursty nature of the stock market, a system that phase-space-wise resides in between the collective intention of e-mail communication and the pure stochasticity of physical avalanches.

Barabasi writes "Bursts" as a hybrid historical/scientific narrative: he switches back and forth between medival Hungarian history and contemporary scientific stories as to how bursts can be discovered in the data we all produce. By the data we all produce, I mean that his examples focus on social phenomena such as e-mail transactions and human mobility patterns. Besides his own work, the book also features the work of Dirk Brockmann, a physicist who did an experiment tracking the movement of dollar bills around the United States. The outcome was that dollar bills diffuse according to a Levy process, or a 1/f form of diffusion. In a Levy flight, which has also been observed for albatross foraging behaviors, short and randomly oriented trips are punctuated by rare, long-distance trips. As with e-mail communications, these bursts are driven in part by intention. It is only when these intentions are joined to chance events and then placed into the context of a process that unfolds over time that the burstiness of behavior becomes apparent.

Conclusion

But what can be learned from the sojourns into history? There is a strong undercurrent of historical contingency in the stories Barabasi selects. Intentional or not, the point is made as to the "burstiness" of how history unfolds. Historical contingency, which refers to the dependence of current events on the trajectory of past events, is not a purely a deterministic process. While the path history takes is constrained by past events, those defining events occur in a background of chance events. Often when people tell stories about how they got a particular job or how they met a spouse, it often involves the phrase "as luck would have it". But perhaps bursts, made manifest by dating websites, commuter trains, and scheduling constraints, are more responsible for these chance events than has traditionally been recognized.

Pac-Man as Google Doodle

Logged onto the internet this morning, and found the Pac-Man Doodle, celebrating the 30th anniversary of the famous video game.

Be careful, it's interactive (and addictive)! The embedded game sounds took me by surprise. Watch it again and again here.

EASTER EGG: If you click on the "Insert Coin" button twice during the same game, Ms. Pac Man appears alongside Pac-Man. You will need to use a second player controller to move the other Pac-person, though.

Nature's method of the year, 2009 - iPS

Here is an excellent video from the Nature publishing group on their method of the year for 2009, induced pluripotent (iPS) cells. Follows are some select screenshots from the video (available on YouTube) with annotation:

How can we reproduce the properties of embryonic stem cells cheaply and somewhat efficiently?

By delivering just four factors (via retroviral vector), we can convert somatic cells into pluripotent ones. While not every exposed cell converts, we can convert enough cells to form self-sustaining colonies.

While the goal is to make fully pluripotent cells for experimentation and perhaps even therapy, cells may also be hijacked (e.g. moved towards a pluripotent fate and then differentiated into another somatic cell type). For example, neurons might be made from fibroblasts in this manner. While not a common technique, one round of infection can produce many cells that are partially reprogrammed (that have some but not all the traits of a truly pluripotent cell).

Advances in Neuroengineering

A recent event put on by the IEEE EMBS focused on recent advances in Neuroengineering, or the interfacing of the nervous systems. Neuroengineering is an emerging approach to treating disabilities, understanding the brain, and building closed-loop control systems for brain-machine computer applications. Here are the sessions (on IEEE.tv):

Advances in neuroengineering

Understanding and treating conditions of the brain

One interesting topic brought up at these session was "microsleeps". Using advanced monitoring techniques, the presence of signatures akin to attentional lapses have been discovered. Microsleeps are sleep states that last on very short time scales. The presence of microsleeps could only be detected using electrophysiological techniques. This might be useful in predicting the onset of apnea episodes, or instances when a driver or heavy machine operator is about to deficus from their
task.

There are also therapeutic applications of these methods. The most intriguing would be to couple the real-time monitoring of muscle and brain activity with cutting edge gene and cell therapy treatments. The videos are worth the watch.